Saturday, March 26, 2011

10. What to do Instead to Avoid Heart Disease

If statins don't work in the long run, then what can you do to protect your heart from atherosclerosis? My personal opinion is that you need to focus on natural ways to reduce the number of small dense LDL particles, which feed the plaque, and alternative ways to supply the product that the plaque produces (more about that in a moment). Obviously, you need to cut way back on fructose intake, and this means mainly eating whole foods instead of processed foods. With less fructose, the liver won't have to produce as many LDL particles from the supply side. From the demand side, you can reduce your body's dependency on both glucose and fat as fuel by simply eating foods that are good sources of lactate. Sour cream and yogurt contain lots of lactate, and milk products in general contain the precursor lactose, which gut bacteria will convert to lactate, assuming you don't have lactose intolerance. Strenuous physical exercise, such as a tread machine workout, will help to get rid of any excess fructose and glucose in the blood, with the skeletal muscles converting them to the much coveted lactate.

Finally, I have a set of perhaps surprising recommendations that are based on research I have done leading to the two papers that are currently under review (Seneff3 et al, Seneff4 et al.). My research has uncovered compelling evidence that the nutrient that is most crucially needed to protect the heart from atherosclerosis is cholesterol sulfate. The extensive literature review my colleagues and I have conducted to produce these two papers shows compellingly that the fatty deposits that build-up in the artery walls leading to the heart exist mainly for the purpose of extracting cholesterol from glycated small dense LDL particles and synthesizing cholesterol sulfate from it, providing the cholesterol sulfate directly to the heart muscle. The reason the plaque build-up occurs preferentially in the arteries leading to the heart is so that the heart muscle can be assured an adequate supply of cholesterol sulfate. In our papers, we develop the argument that the cholesterol sulfate plays an essential role in the caveolae in the lipid rafts, in mediating oxygen and glucose transport.

The skin produces cholesterol sulfate in large quantities when it is exposed to sunlight. Our theory suggests that the skin actually synthesizes sulfate from sulfide, capturing energy from sunlight in the form of the sulfate molecule, thus acting as a solar-powered battery. The sulfate is then shipped to all the cells of the body, carried on the back of the cholesterol molecule.

Evidence of the benefits of sun exposure to the heart is compelling, as evidenced by a study conducted to investigate the relationship between geography and cardiovascular disease (Grimes et al., 1996). Through population statistics, the study showed a consistent and striking inverse linear relationship between cardiovascular deaths and estimated sunlight exposure, taking into account percentage of sunny days as well as latitude and altitude effects. For instance, the cardiovascular-related death rate for men between the ages of 55 and 64 was 761 in Belfast, Ireland but only 175 in Toulouse, France.

Cholesterol sulfate is very versatile. It is water soluble so it can travel freely in the blood stream, and it enters cell membranes ten times as readily as cholesterol, so it can easily resupply cholesterol to cells. The skeletal and heart muscle cells make good use of the sulfate as well, converting it back to sulfide, and synthesizing ATP in the process, thus recovering the energy from sunlight. This decreases the burden on the mitochondria to produce energy. The oxygen released from the sulfate molecule is a safe source of oxygen for the citric oxide cycle in the mitochondria.

So, in my view, the best way to avoid heart disease is to assure an abundance of an alternative supply of cholesterol sulfate. First of all, this means eating foods that are rich in both cholesterol and sulfur. Eggs are an optimal food, as they are well supplied with both of these nutrients. But secondly, this means making sure you get plenty of sun exposure to the skin. This idea flies in the face of the advice from medical experts in the United States to avoid the sun for fear of skin cancer. I believe that the excessive use of sunscreen has contributed significantly, along with excess fructose consumption, to the current epidemic in heart disease. And the natural tan that develops upon sun exposure offers far better protection from skin cancer than the chemicals in sunscreens.

20 comments:

dim said...

Una obra maestra! Thank you for such a clear and enlightening presentation. I learned a lot in this serie about atherosclerosis and heart disease.

I am looking forward to benefit again from your impressive research.

Thanks again

MsDidi said...

My problem for sun exposure is that my skin is very fair and I burn before I tan. I would love to do all I can by ensuring I get sulphates and understand it is absorbed by the sun, but I am getting the that point of having a few sunspots and blotchy skin. My doctor prescribed retinol to help even the tone. I do not use sunscreen on my leggs and arms much but I live in a cold climate with less than otptimal sun in winters.

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Unknown said...

Great research Doctor.Would supplemental sulphur "msm" reduce my coronary calcium score.

John said...

Hi Stephanie,
You make a compelling argument. I wonder what the best way is to supplement the body safely with Cholesterol sulfate without it exerting thrombogenic effects, as it has been shown to induce platelet aggregation? Regently I developed angina that went from stable to acutely unstable and fortunately got to an emergency room and a hospital equipped with PCI. Only one artery was affected. Now I'm on Lipitor, which I'd like to have reduced to minimal dosage by my next doctor's visit. I supplement with ubiquinol, among other things, mostly antioxidants. So, I will resume eating whole eggs and try to get more sunshile, possibly supplement with acetyl-L-Cysteine. I'm also on blood thinners because of the stents I received and would not want to counteract that, as I have read multiple sources showing cholesterol sulfate to promote thrombus. Your learned advice would be most appreciated as I walk this balancing act.

Unknown said...

Good research Doctor

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Unknown said...

I have had a stent placed in the LAD after emergency AMCI in Maui. In come for 12 days but released from hospital on the 21st day. 58 yrs old male without any prior medical conditions. Came on after morning tennis at relaxed pace. I could tell something was wrong and told daughter. Half hour later full blown AMCI. Total amnesia after and don't even rember anything except waking in hospital and not even knowing where I was or what year it was. Have experience with alternative treatments for many afflictions. Lipid profile is rather normal. Hdl 47 LDL 67 total cholesterol 136 triglycerides 160 BP 130/86-110/58 . On brilliant a,metoprolol, Lipitor, lisinopril, aspirin, and hydrochlorate diuretic.
Question for Stephanie
: 1) how does heart use cholesterol sulfate?
What role does it play and why is it so important that the body finds other ways to assure supply ie plaque.?
3) Dr Morrison proposed chondrotin sulfate as a molecule to clean arteries of plaque with very good results. Is cholesterol sulfate a GAG like chondroitin sulfate and heparin sulfate? And is it functioning in much the same way? Have you done work with chondroitin sulfate to clear arteries and supply heart with energy or arterial repair? I think there're might be some synergy between chondroitin sulfate and cholesterol sulfate? Thanks in advance...

Kang Nurul Iman said...

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Unknown said...

Diet and exercise are important factors that impact heart health in men. when diet and exercise are not enough, supplements may help you to get your cholesterol levels under control. New chapter cinnamon force

Unknown said...

While it seems getting to make Cholesterol sulphate in the body with exposure to sunlight, a great idea, ( as compared to vitamin D supplements, which do not make the sulphates anyway )what would one suggest to people like me who do not use sunscreens but on exposure to even 5 minutes of sunlight get skin eruptions in the exposed part.
Is this due to some deficiency in the body.

Most of the doctors just suggested to use sunscreen creams........That is not a solution.....
Can anybody help me?
Thanks

Unknown said...

Prepare by taking 5000 iu vitamin d3 daily for at least a week. Then spend max 20 minutes in mid day sun with zero sunscreen. When you don't get red you can add 10 minutes a day, and so on. You may also get red in sun from lack of vitamin d3. Take only 100 mg 1st time and if no reaction double next day. Do not use a "flush free" b3. When you feel itchy and skin gets patchy red - inside away from sun
- you are replenishing B3. Next day in sun you know if sensitivity was lack of B3 or general sensitivity to sun .
Farm workers from Europe often got red necks in the us sun, mainly because lack of b3. They prepared corn in a way so that all the b3 was lost. Cheers to all modern times rednecks !




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