Saturday, March 26, 2011

8. Statins and the Brain

While the brain is not the focus of this essay, I cannot resist mentioning the importance of cholesterol to the brain and the evidence of mental impairment available from our data sets. Statins would be expected to have a negative impact on the brain, because, while the brain makes up only 2% of the body's weight, it houses 25% of the body's cholesterol. Cholesterol is highly concentrated in the myelin sheath, which encloses axons which transport messages long distances (Saher et al., 2005). Cholesterol also plays a crucial role in the transmission of neurotransmitters across the synapse (Tong et al, 2009). We found highly skewed distribution of word frequencies for dementia, Parkinson's disease, and short term memory loss, with all of these occurring much more frequently in the statin reviews than in the comparison reviews.

A recent evidence-based article (Cable, 2009) found that statin drug users had a high incidence of neurological disorders, especially neuropathy, parasthesia and neuralgia, and appeared to be at higher risk to the debilitating neurological diseases, ALS and Parkinson's disease. The evidence was based on careful manual labeling of a set of self-reported accounts from 351 patients. A mechanism for such damage could involve interference with the ability of oligodendrocytes, specialized glial cells in the nervous system, to supply sufficient cholesterol to the myelin sheath surrounding nerve axons. Genetically-engineered mice with defective oligodendrocytes exhibit visible pathologies in the myelin sheath which manifest as muscle twitches and tremors (Saher et al, 2005). Cognitive impairment, memory loss, mental confusion, and depression were also significantly present in Cable’s patient population. Thus, his analysis of 351 adverse drug reports was largely consistent with our analysis of 8400 reports.


Leila said...

Stephanie, question for you - what would cause a tripling in cholesterol levels in six months?

The patient is my son Leo, age 27. He had surgery for a medullablastoma 20 years ago, with a vp shunt insertion & followup radiation therapy. Nothing happened thereafter, medically, until last summer, when the shunt became blocked & had to be revised; and he had another shunt revision 2 weeks ago.

He had a stroke about a week after last summer's surgery & the docs have been trying to figure out why ever since, with no luck. His bloodwork indicates an increase in his cholesterol levels from 2-something to 6-something, over the past few months.

I'm wondering why all this is happening now, 20 years after the main event, & what to do about it. He was having some fairly severe hydrocephalus symptoms, both last year & 2 weeks ago, so I'm guessing the cholesterol increased in response as a protective measure, and that it will drop spontaneously. The docs think I'm nuts.

I appreciate any insight you can give.

suzana martin said...

The NES Health program starts with a body field assessment, which involves simply resting your hand on a palm-sized scanner device for 20 seconds. Your Human Body-Field is then scanned monitoring the quality of its responses and then prioritising the results. And the result is of course good and it's for your alternative health.

Blogger said...

Informative article. Well appreciated. Thank you so much for sharing this post. Get to know about the best medical scanning centre in Kerala.

Aswin said...

Nice post. Thanks for sharing this content. Know about the best PET scan in Kerala & cancer specialist in Kerala.