Thursday, December 17, 2009

APOE-4: The Clue to Why Low Fat Diet and Statins may Cause Alzheimer's


Alzheimer's is a devastating disease whose incidence is clearly on the rise in America. Fortunately, a significant number of research dollars are currently being spent to try to understand what causes Alzheimer's. ApoE-4, a particular allele of the apolipoprotein apoE, is a known risk factor. Since apoE plays a critical role in the transport of cholesterol and fats to the brain, it can be hypothesized that insufficient fat and cholesterol in the brain play a critical role in the disease process. In a remarkable recent study, it was found that Alzheimer's patients have only 1/6 of the concentration of free fatty acids in the cerebrospinal fluid compared to individuals without Alzheimer's. In parallel, it is becoming very clear that cholesterol is pervasive in the brain, and that it plays a critical role both in nerve transport in the synapse and in maintaining the health of the myelin sheath coating nerve fibers. An extremely high-fat (ketogenic) diet has been found to improve cognitive ability in Alzheimer's patients. These and other observations described below lead me to conclude that both a low-fat diet and statin drug treatment increase susceptibility to Alzheimer's,


Conway Calin said...

Nice Post,
buy kamagra online,
buy kamagra,
buy cheap kamagra

cv writing service said...

I personally feel that one need to have controlled and healthy diet than low fat diet. we unconsciously do wrong with our health in the name of diet. Going to share this post with my friends so that they can be aware of it. thanks for sharing it

Blogger said...

Excellent information. I would like to say thank you for sharing this article. Know about the best pathology lab in India.